17^th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology June 21-22, 2021 Amsterdam, Netherlands

Biography:

Ms. Linda Jeeva Kumari H. is a Ph.D. scholar at the University College of Engineering (UCE), Anna University, Tiruchirappalli, Tamil Nadu, India. She has received a master’s degree in biotechnology from PSG College of Technology, Coimbatore, India. Her research interests are drug delivery and pulmonary pharmacology. She has worked as a Junior Research Fellow in the Department of Science and Technology, Government of India sponsored National Facility for Drug Development for Academia,Pharmaceutical and Allied Industries, Anna University, Tiruchirappalli. She has actively participated in various international conferences and has published 11 papers in peer-reviewed journals (cumulative impact factor 32.459).   

 

Abstract:

Nanoparticle-based drug delivery systems are developed to target alveolar macrophages associated with pulmonary inflammation. Allergic asthma is a chronic inflammatory lung disease characterized by airway hyperresponsiveness, airway inflammation and goblet cell hyperplasia to inhaled allergens and nonspecific stimuli. Peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear hormone receptor is expressed in the structural and inflammatory cells of the lungs that regulates inflammatory responses in asthma pathophysiology. Galangin, a flavonoid present in Alpinia officinarum is a PPARγ agonist proven to possess anti-asthmatic property. Despite the potent therapeutic efficacy of galangin, poor aqueous solubility limits its pharmacological activity. Polymeric nanoparticles are biocompatible, safe and stable with sustained release property which are required for better therapeutic applications. Hence, nanoparticle-based approach was adopted to enhance the therapeutic efficacy of galangin, forming the rationale of the study. Activation of PPARγ may also occur by ligand-independent transcriptional activity, and conversely, the ligand may follow PPARγ-independent pathway. Therefore, our hypothesis is that galangin loaded polymeric nanoparticles (G-NPs) could enhance the anti-asthmatic effect of encapsulated galangin over free galangin via PPARγ-dependent pathway. In this study, G-NPs were prepared and characterized. In vitro drug release and hemocompatibility studies were performed. In vivo anti-asthmatic studies in ovalbumin-induced murine model were performed, wherein, G-NPs significantly ameliorated the pro-inflammatory mediators. Expression (mRNA and protein) analyses confirm the mechanistic action of PPARγ. Taken together, our findings communicate that nanoencapsulated compound exhibited better anti-asthmatic activity over free compound by suppressing the pro-inflammatory mediators via PPARγ-dependent pathway, thereby implying PPARγ as a therapeutic target for asthma.

 

Biography:

Master of nanotechnology from School of Physics, Universiti Sains Malaysia. Nabeel does research in Applied Mathematics, Solid State Physics, and Nanotechnology, A specialty is 'Electrospinning for applications of sensores and solar cells . Nabeel teacher of physics in Gifted Students School in Anbar, Iraq. He currently PhD student in Institute of Nano-Optoelectronics Research and Technology (iNOR)-Malaysia. He has 11 publications that have been cited 30 times and has shared a chapter in book above 2000 download with citation 10 times, his publication H-index is 3 and he reviewed some manuscripts for reputed Journals in IOP, Springer and Elsivier.

Abstract:

The Human is the most important creature in this great universe. This great human organs of the body and the cells, it is threatened the existence of diseases that afflict him, and we know for sure that this great body the ability to resist most diseases. It is known that some diseases triumph over this great body and an example of this is cancer, so in many cases their lives end of many humans because of the disease. My study today is a simple report and a call to all researchers to turn to the important thing that is the intelligence of human body cells, which I believe to tell us of any damage that tries to harm this body. The body that tells us when it needs to water by thirst state., moreover, why do we choose a specific type of eating or a specific fruit can tell us about cancer early, all of this is a translation of what the body needs. So we need to listen and translate what are cells need to understand much of what happens to the body, and also very early detection of most cancers that occur to the body.

Biography:

Mr Kiyemba ronald DOB, 07-02-1979 in Uganda Kampala. Coach for Uganda cycling national teams, holding a degree in sports science. President, KITANDA CARE for HIV/Aids & UTI infections control Owner of, Bike 2 Bike tours (U) LTD

 

Abstract:

1. Statement of the problem

Substance abuse is popular on the increase in our low income setting today for various reasons and is associated with poverty as a major risk factor.

In Uganda mental illness has become common in sports and is often associated with substance enhancement from alcohol and marijuana intake. Some of the factors that have promoted this rise include physical pain, chronic injuries and pressure to produce results. The overall effect of this problem has led to addiction, low productivity, social dissociation and finally failure to perform in sports.

2. Methodology and theoretical orientation

We reviewed articles and references of related topics finding those relevant to the scope of the subject.

Objectively closed ended questioners were given to 380 sports participants chosen from 12 sports centers (Pilot) areas under random distribution in 4 different regional urban setting in Uganda.

They were assessed on modified additional and productivity scales.

3. Findings

Northern region n=60 12 normal 48(80%) Addiction low productivity 0.83(83.3%), Eastern region n=100 20 normal subjects, Addiction 40(40%) low productivity 47(47%). Western region n=90 Addiction 23(25.5%) low productivity 52 (57.7%)

Central region n=130 Addiction 68(52.3%) low productivity 39(30%)

3. Conclusion:

Urban region e.g. Central have highest rates of Addiction with low productivity due availability of drugs and cheap alcohol/spirits on the market. Restrictions on alcohol is not observed within the local communities in the rural regions Sports men have highest low productivity due to poor social support, unemployment and no formal infrastructure.

5. Significancy

Addiction and low productivity have affected the sports industry in Uganda leading to poor performance in sports.

Biography:

Dr. M. P. Venkatesh has completed his Masters program in Industrial Pharmacy from RGUHS, Bangalore (2006) and PhD from JSS University, Mysuru (2013). He is the Assistant Professor in Dept.of Pharmaceutics, JSS College of Pharmacy, Mysuru. He has published more than 50 papers in reputed journals and has been serving as an reviewer for many reputed journals in related areas of research. He has guided more than 30 M.Pharm and MDS students and currently gudiing 6 Ph.D. scholars and 6 M.Pharm students. He is working on novel delivery systems for effective managament of rheumatoid arthritis. 

Abstract:

The present study aims to develop MTX-S (Methotrexate sodium) in situ gels as an effective way for the treatment of rheumatic arthritis (RA). The in situ gels composed of Pluronic F-127 as a polymer and Hydroxy Propyl Methyl Cellulose K4M (HPMC K4M) and Polycarbophil (PCL) as copolymers were manufactured by cold method. The in situ gels were characterized for gelation time, gelation temperature, syringeability, viscosity, sterility, in vitro release and drug content. The biocompatibility and efficacy of MTX-S in situ gels ascertained using histology analysis and Freund’s complete adjuvant model respectively. The results of the present study showed that the optimized formulation (M4) was thermo-sensitive and exhibited drug release of 93.26±2.39 at 96 h. Moreover, MTX-S was evenly distributed in the optimized formulation which was sterile and syringeable through 18 gauze needle. In vivo study on the wistar rats showed significant decrease in rat paw volume during a 28 day study period. Thus, MTX-S in situ gel could be successfully used for targeting specific treatment of RA.

Biography:

Oral delivery is considered the favoured route of administration for both local and systemic delivery of active molecules (1). Formulations of drugs in lipid-based delivery systems as nanoemulsions (NE) have drawn increasing attention in the last decade for their great potential to improve oral delivery of poorly water-soluble drugs (2). In this work a rational design to obtain novel NE has been carried out. Stability in simulated gastric fluid (SGF) and simulated intestinal fluid in fasted state (FaSSIF-V2), and mucopenetratign properties of NEs were studies. Moreover, we reported the optimization of drying processes to improve systems stability. In view of prolonging drug intestinal residence time NE were embedded in a mucoadhesive chitosan (CH) sponge to obtain a nanocomposite. Chitosan, a high mucoadhesive polysaccharide, biocompatible and biodegradable has been selected to its ability to adhere to the mucosal epithelium. The unique physicochemical, structural and biopharmaceutical aspects associated to CH-loaded NE nanocomposites for improving oral drug delivery have been studied (3). The nanocomposite was successfully obtained and using microscopy techniques (SEM and optical microscope) we were able to characterize the structure of the system. Lastly, the nanocomposite oral administration to mice proved the effectiveness in increasing the NE intestinal residence time. Overall, the approach here presented provide a template for developing nanoemulsion-based nanocomposite intended for oral delivery of drugs.

Abstract:

Dr. Giovanna Lollo is Assistant Professor at the Faculty of Pharmacy, University Claude Bernard Lyon 1 (France). In 2012 she received Ph.D. in Pharmaceutical Technology at the University of Santiago de Compostela (Spain). Then, she joined the MINT laboratory at University of Angers (France) where she worked as postdoc developing novel nano-immuno-chemotherapeutic approaches to defeat cancers. Currently, her research is directed towards the design of novel nanosystems to cross biological barriers reaching pathological sites without compromising healthy tissues, with applications in oncology and autoimmune diseases. She has authored more than 30 peer-reviewed articles and has issued 3 patents (one licenced).

Biography:

He is working as an Assistant Professor in the department of pharmaceutics at ISF College of Pharmacy, Moga, Punjab. He did M. Pharmacy from ISF College of Pharmacy, Moga, Punjab. He is pursuing his Ph.D. from MRSPTU, Bathinda He has published more than 40 review and research articles in various reputed journals. He has published more than 3 book chapters. He has qualified for the GPAT test 2 times. He has more than 4.8 years of teaching experience. He has guided more than 15 graduate students. He was the brand ambassador of Bentham science-2020. He has also participated and presented his research work at various national and international conferences.

Abstract:

The objective of this study was to develop and characterize enteric-coated pectin pellets containing mesalamine and S.bulardii for specific colon targeted drug delivery for ulcerative colitis management. Pellets of mesalamine and S.bulardii were produced by extrusion- spheronization technique by using pectin and microcrystalline cellulose and coated with Cellulose acetate phthalate. The pellets were evaluated for morphology, micromeritic properties as well as through fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction techniques and the results confirmed that all the ingredients of the pellets were compatible with each other without revealing any specific interaction. The dissolution profiles of uncoated and coated pellets were examined at pH 1.2, 6.8 and 7.4 with and without rat cecal content. Further pharmacokinetic studies revealed a lower value of maximum concentration in the case of cellulose acetate phthalate coated pellets formulation in comparison to uncoated ones which, evidenced the lower systemic exposure of the drug. Finally, to ensure the therapeutic activity of the selected formulation, a 2,4,6- trinitrobenzene sulfonic acid-induced colitis model was used. Colon/ Bodyweight ratio, myeloperoxidase, lipid peroxidase level, glutathione activity and histological evaluation were performed in the colitis model. Animal experiments revealed that coated pellets of mesalamine and S.bulardii significantly improved the diseased conditions in Wistar rats. The confirmation of which was done by the gain in weight, clinical improvement in macroscopic and microscopic factors of induced colitis. These findings ensure that coated pellet formulation has promising potential for targeted drug delivery of mesalamine and S.bulardii to the colon as well as to improve the viability of probiotics and enhancement in the effectiveness of mesalamine in management of ulcerative colitis.