Seitaro Kamiya
Nagasaki International University, Japan
Title: A physicochemical study on the preservation of nanoparticles
Biography
Biography: Seitaro Kamiya
Abstract
The importance of nanoparticle formulation is increasingly recognized in supporting pharmaceuticals development. Thus, maintaining a constant state in nanoparticles is an important major issue. A method involving lyophilization with the addition of saccharides can be used to maintain the state of nanoparticles. In drugs; however, this method has not been sufficiently discussed. In this study, trisaccharides, tetrasaccharides, and pentasaccharides were added to the nanoparticle suspensions, followed by rehydration of the samples, which had been either dried normally or freeze-dried. The particle diameter size after rehydration at that time was then measured. In addition, each saccharide was measured using a powder X-ray diffractometer and differential scanning calorimetry (DSC) device. We studied the association between the nanoparticles aggregation and the crystal form of saccharides and their mechanisms by using the obtained results of the data of particle size, powder X-ray pattern, and DSC curves. The diameter of the nanoparticles was maintained when it was freeze-dried, while particle aggregation occurred when normal dried samples were used. In addition, crystallinity crystalline saccharide was not observed in the freeze-dried group but was in the normal dried group.