Nanomedicine and Pharmaceutical Nanotechnology

Biography

Biography: Sophie Franceschi

Abstract

In recent years, a growing interest has emerged in the development of semi-solid colloidal careers for the delivery of water-insoluble drugs. Solid lipid Nanoparticles (SLN) and Nanostructured Lipid Careers (NLC) are example of such systems. As an alternative to SLN, we propose the use of an original family of organogel nanoparticles. Organogels are semi-solid materials in which an organic solvent (e.g., vegetable oil) is entrapped in the three-dimensional fibrous network formed by self-aggregation of a low molecular mass organic gelator (12-Hydroxystearic acid). The preparation process of the gelled oil nanoparticles is based on the sol-gel phase transition of the organogel obtained by hot emulsification (T°>T°gel) in presence of an aqueous solution of stabilizing agent (Polyvinylalcohol 80), leading to a stable semi-solid dispersion after cooling (T°In vitro dialysis release experiments showed different kinetic profiles in comparison with control buffer solutions, underlying the importance of the drug solubility in the gelled oil and its possible ionization in water. The results obtained have enabled us to evaluate the drug delivery capabilities of these gelled particles and their possible use in different pharmaceutical pathways (oral or skin).